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Dr. Eimear Mc Glinchey
Assistant Professor, School of Nursing & Midwifery

Biography

r Eimear McGlinchey is an Assistant Professor in Intellectual Disability in the School of Nursing and Midwifery, and a Senior Atlantic Fellow for Equity in Brain Health at the Global Brain Health Institute.

Eimear's background is in Psychology and her primary area of interest is in the promotion and maintenance of brain health in people with an intellectual disability, with particular focus on the area of dementia in people with Down syndrome. Eimear's work in the area of dementia and Down syndrome includes investigating early biomarkers of Alzheimer's disease using neuroimaging, blood- based and cognitive biomarkers and is PI of the PREVENT dementia - DS project. This project is part of a collaborative international study with the Horizon 21 European Down syndrome Consortium. Dr McGlinchey is co-PI on a project that includes the voices of people with an intellectual disability in developing guidelines for post-diagnostic dementia support.

Eimear's work is based in the Trinity Centre for Ageing and Intellectual Disability and is research lead with the National Intellectual Disability Memory Service. Her other areas of interest include equity and inclusion as well as accessibility and innovative dissemination.

Eimear teaches on the undergraduate and postgraduate programmes in the school and provides supervision to undergraduate, masters and PhD students. She is Program Director for the Ageing Health and Wellbeing in Intellectual Disability MSc, the Dementia MSc, and the Community Health MSc in the School of Nursing and Midwifery. She has a number of publications and has disseminated widely through national and international conferences.

Publications and Further Research Outputs

Peer-Reviewed Publications

McCarron, M., McCausland, D., McGlinchey, E., Bowman, S., Foley, M., Haigh, M., Burke, E. & McCallion, P., Recruitment and retention in longitudinal studies of people with intellectual disability: A case study of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA), Research in Developmental Disabilities, 124, 2022 Journal Article, 2022 DOI

Marianne Fallon, Eimear McGlinchey, Philip McCallion, Mary McCarron, Developing A Biopsychosocial Model of Cognitive Decline in People Ageing with Intellectual Disability, IASSIDD Virtual 2021, Amsterdam, the Netherlands, 6-8th July 2021, 2021 Conference Paper, 2021 URL

Marianne Fallon, Eimear McGlinchey, Philip McCallion, Mary McCarron, Developing A Biopsychosocial Model of Cognitive Decline in People Ageing with Intellectual Disability, IASSIDD Virtual 2021, Amsterdam, the Netherlands, 6-8th July 2021, 2021 Oral Presentation, 2021 URL URL

McCarron, M., Allen, A., McCausland, D., Haigh, M., Luus, R., Bavussantakath, F.R., Sheerin, F., Mulryan, N., Burke, E., McGlinchey, E., Flannery, F. & McCallion, P., The impact of COVID-19 on people ageing with an intellectual disability in Ireland: Protocol for a follow-up survey., HRB Open Research, 4, (95), 2021 Journal Article, 2021 DOI

Marianne Fallon, Eimear McGlinchey, Philip McCallion, Mary McCarron, Using Health Psychology Theory to inform research into Cognitive Decline in People with Intellectual Disability, Psychology, Health and Medicine , University College Cork, 12th-14th May 2021, 2021 Poster, 2021 URL URL

McCarron, M., McCausland, D., Luus, R., Allen, A., Sheerin, F., Burke, E., McGlinchey, E., Flannery, F. & McCallion, P., The impact of coronavirus disease 2019 (COVID-19) on older adults with an intellectual disability during the first wave of the pandemic in Ireland, HRB Open Research, 4, (93), 2021 Journal Article, 2021 DOI

Boyle, R., Connaughton, M., McGlinchey, E., Knight, S.P., De Looze, C., Carey, D., Stern, Y., Robertson, I.H., Kenny, R.A. and Whelan, R, Connectome‐based predictive modeling of cognitive reserve, Alzheimer's & Dementia, 7, (S5), 2021 Journal Article, 2021 DOI

McGlinchey, E., McCallion, P., & McCarron, M., Patterns of onset of dementia and epilepsy in adults with Down syndrome: Findings from IDS-TILDA., Trinity Health and Education International Research Conference 2021 (THEconf2021): 'Transforming healthcare in a changing world: new ways of thinking and working', Dublin, 9th - 11th March, 2021 Oral Presentation, 2021 URL

Ageing with Intellectual Disability: Dementia and Cognitive Decline in, editor(s)J. Matson , Handbook of Dual Disorders, Springer Link, 2020, pp311 - 330, [Sheerin F, McCallion P, McGlinchey E, O'Dwyer M, Reilly E, McCarron, M ] Book Chapter, 2020

Roe, L., Galvin, M., Booi, L., Brandao, L., Salas, J. L., McGlinchey, E., & Walrath, D., o live and age as who we really are: Perspectives from older LGBT+ people in Ireland., HRB Open Research, 3, (6), 2020 Journal Article, 2020 DOI

McGlinchey, E., McCallion, P., McCarron, M., Down syndrome and Dementia: Advances in the field, Current Opinion in Psychiatry, 33, (3), 2020, p278 - 283 Journal Article, 2020 DOI

Young,P., Estarella, M., Coomans, E., Srikrishna, M., Beaumont,H., Maass, A., Venkataraman, A., Lissaman,R., Jiménez, D., Betts, M.J., McGlinchey, E., Berron, D., O'Connor,A., Fox, N., Pereira, J., Jagust, W., Carter, S., Paterson, R., Schöll, M., Imaging Biomarkers in Neurodegeneration: Current and Future Practices, Alzheimer's Research and Therapy , 12, (49), 2020 Journal Article, 2020 DOI

McGlinchey, E., McCallion, P., McCarron, M., Developing National Positive Ageing Indicators for People with an Intellectual Disability in Ireland, JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, IASSIDD World Congress, Glasgow, August 2019, 63, (7), Wiley, 2019 Oral Presentation, 2019 DOI

McGlinchey, Eimear; McCarron, M., Holland, AJ., McCallion, P , Examining the effects of computerised cognitive training on levels of executive function in adults with Down syndrome, Journal of Intellectual Disability Research, 63, 2019, p1137 - 1150 Journal Article, 2019 DOI

Dementia and Intellectual Disability: Prevalence, Assessment and Post-Diagnostic Support in, editor(s)Johnny Matson , Handbook of Intellectual Disabilities, Springer , 2019, pp965 - 986, [Eimear McGlinchey, Evelyn Reilly, Philip McCallion, Pamela Dunne, Niamh Mulryan, Mary McCarron] Book Chapter, 2019 URL

McGLinchey, E., Whelan, R., McCarron, M. , Dementia in People with Down syndrome: An Underrepresented Population, Engage Dementia , Croke Park, Dublin , May, 2019, 2019 Oral Presentation, 2019

McGlinchey, E., McCallion, P., McCarron, M., Developing National Positive Ageing Indicators for People with an Intellectual Disability in Ireland, JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, IASSIDD World Congress, Glasgow, August 2019, 63, (7), Wiley, 2019 Oral Presentation, 2019

McGlinchey, E., McCallion, P,, McDermott, S., Foley, M., Burke, E.A., O'Donovan, M-A., McCausland, D., Gibney, S., McCarron, M. , Positive Ageing Indicators for People with an Intellectual Dsiability 2018, Dublin: Trinity Centre for Ageing and Intellectual Disability, 2019 Report, 2019 URL

Mac Giolla, Phadraig C., McCallion, P., McGlinchey, E., Nunn, J., McCarron, M, Communication-based behavior support for adults with intellectual disabilities receiving dental care: A focus group study exploring dentists' decision-making and communication., Journal of Intellectual Disability Research, 23, (4), 2019, p526 - 540 Journal Article, 2019

McGlinchey, E., McCallion, P. & McCarron, M., Inclusion of people with Down syndrome in dementia research: Awareness, engagement and attitudes., Journal of Intellectual Disability Research, The World Congress of the International Association for the Scientific Study of Intellectual and Developmental Disabilities, Glasgow, Scotland, 6th - 9th August, 63, (7), 2019 Oral Presentation, 2019 DOI

McGlinchey, E., McCallion, P., McCarron, M., Patterns of dementia and epilepsy in adults with Down syndrome in Ireland: data from IDS-TILDA, JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, IASSIDD European Congress, Athens, May 2018, 31, (4), Wiley, 2018, pp552 - 552 Oral Presentation, 2018

Ouellette-Kuntz, H., Martin, L., Burke, E., McCallion, P., McCarron, M., McGlinchey, E., Sandberg, M., Schoufour, J., Shooshtari, S., Temple, B, How best to support individuals with IDD as they become frail: Development of a Consensus Statement, Journal of Applied Research in Intellectual Disabilities , 32, (1), 2018, p35 - 42 Journal Article, 2018 URL

Overview of the Important Physical Health Concerns in, editor(s)Vee P. Prasher and Matthew P. Janicki , Physical Health of Adults with Intellectual Disabilities, Springer Nature, 2018, [Burke, E.A., O'Dwyer, M., McGlinchey, E., Foran, S., MacGiolla Phadraig, C., Carroll, R., McCallion, P. and McCarron, M] Book Chapter, 2018 DOI

The Test for Severe Impairment in, Neuropsychological Assessments of Dementia in People with Down syndrome and Intellectual Disabilities, 2017, [McCarron, M., Carroll, R., Mulryan, N., Reilly, E., Dunne, P., McGlinchey, E., McCallion, P., ] Book Chapter, 2017

McGlinchey, E., McCarron, M, Cognitive Training with Adults with Down syndrome, 2017 International Summit on Ageing with an Intellectual Disability, TBSI Dublin, 20th September, 2017 Oral Presentation, 2017

McGlinchey, E., McCarron, M., McCallion, P, Conducting a feasibility study on cognitive training with adults with Down syndrome: Methodology and lessons learned, 2016 IASSIDD World Congress, Melbourne, 15-19 August 2016, 2016 Oral Presentation, 2016

McGlinchey, E., McCarron, M., McCallion, P, The impact of Cognitive Training on Executive Function in Adults with Down syndrome, 2016 IASSIDD World Congress, Melbourne, 15-19 August 2016, 2016 Oral Presentation, 2016

McGlinchey, E., McCarron, M., McCallion, P, Findings in relation to change in EF scores, IASSID Congress, Melbourne, Australia, 15th - 19th August, 2016 Oral Presentation, 2016

McGlinchey, E., McCarron, M., McCallion, P, Examining the relationship between cognitive reserve and levels of executive function: Results from the BEADS study, 2016 IASSIDD World Congress, 15-19 August 2016, 2016 Oral Presentation, 2016

McGlinchey, E., McCarron, M., McCallion, P, Conducting a feasibility study on cognitive training with adults with Down syndrome: Methodology and lessons learned, 2016 IASSIDD World Congress, Melbourne, 1519 August 2016, 2016 Oral Presentation, 2016

McGlinchey, E., McCallion, P., McCarron, M, Cognitive reserve: Implications for research in dementia for people with down syndrome, Faculty of Health Sciences Research Day, Trinity College, Dublin, 16th September, 2015 Poster, 2015

McCarron, M., O'Dwyer, M., Burke, E., McGlinchey, E., McCallion, P., Epidemiology of Epilepsy in Older Adults with an Intellectual Disability in Ireland, American journal of intellectual disabilities, 2014, p253 - 260 Journal Article, 2014 DOI

Mac Giolla, Phadraig C., El-Helaali, R., Nunn, J H., Burke, E., McCallion, P., McGlinchey, E., McCarron, M , National levels of reported difficulty in tooth and denture cleaning among an ageing population with intellectual disabilities., 15, (3), 2014, p48 - 53 Journal Article, 2014 DOI

Burke E, McCarron M, Carroll R, McGlinchey E, McCallion P, What it's like to grow older: the aging perceptions of people with an intellectual disability in Ireland., Intellectual and developmental disabilities, 52, (3), 2014, p205-19 Journal Article, 2014 DOI

McGlinchey, E., McCarron, M., McCallion, P, Examining the usefulness of measures of executive function in individuals with down syndrome: A comparative review, IASSID, Vienna, July, 2014 Poster, 2014

MacGiolla Phadraig, C., Burke, E., McCallion, P., McGlinchey, E., Nunn, J., McCarron, M, Dental attendance among older adults , Special Care in Dentistry, 2014 Journal Article, 2014 DOI

McGlinchey, E., McCarron, M., McCallion, P, Cognitive reserve: Implications for research in dementia for people with down syndrome, IASSID, Vienna, July, 2014 Poster, 2014

McGlinchey, E., McCallion, P., Burke, E., McCarron, M., Examining the area of Employment for Adults with an Intellectual Disability, 14th Healthcare Interdisciplinary Research Conference & Student Colloqium, School of Nursing & Midwifery, Trinity College Dublin, November, 2013 Oral Presentation, 2013

McCarron, M., Swinburne, J., Burke, E., McGlinchey, E., Carroll, R., McCallion, P, Patterns of multimorbidity in an older population of persons with an intellectual disability: results from the intellectual disability supplement to the Irish longitudinal study on aging (IDS-TILDA)., Research in developmental disabilities, 34, (1), 2013, p521 - 527 Journal Article, 2013 DOI TARA - Full Text

McCarron, M., McGlinchey,E., Burke, E., O'Dwyer, M., McCallion, P., Epidemology of epilepsy in Older Adults with an Intellectual Disability, Irish Journal of Medical Science Volume 182 Supplement 6 DOI 10.1007/s11845-013-0985-z, 61st Annual & Scientific Meeting of the Irish Gerontological Society, Croke Park, 20-21 September, 2013 Poster, 2013

McGlinchey, E., McCallion, P., Burke, E., Carroll, R., McCarron, M, Exploring the Issue of Employment for Adults with an Intellectual Disability in Ireland, Journal of applied research in intellectual disabilities, 26, (4), 2013, p335 - 343 Journal Article, 2013 DOI

McCallion P, Burke E, Swinburne J, McGlinchey E, Carroll R & McCarron M, Influence of environment, predisposing, enabling and need variables on personal health choices of adults with intellectual disability., Health, 5, (4), 2013, p749 - 756 Journal Article, 2013 DOI TARA - Full Text

Understanding the similarities and differences in aging with an intellectual disability: Linking Irish general population and intellectual disability datasets in, editor(s)R. Urbano , Using Secondary Datasets to Understand Persons with Developmental Disabilities and their Families , New York, Academic Press, 2013, pp206 - 233, [McCallion, P., Swinburne, J., Burke, E., McGlinchey, E., McCarron, M.] Book Chapter, 2013 DOI

Burke, E., McCallion, P., McGlinchey, E., McCarron, M., , The Ageing Perceptions of Older Adults with an Intellectual Disability in Ireland, 14th Healthcare Interdisciplinary Research Conference & Student Colloqium, School of Nursing & Midwifery, Trinity College Dublin, November 2013, 2013 Conference Paper, 2013

McGlinchey E, McCallion P, Burke E, Carroll R & McCarron M, Exploring the issue of employment of adults with an intellectual disability in Ireland., JARID, 26, (4), 2013, p335-43 Journal Article, 2013 DOI

McGlinchey, E., Carroll, R., McCarron, M., McCallion, P, An Exploration of the Employment Status of people over forty with an Intellectual disability in Ireland, Irish Gerontology Society Conference, University College Cork, 2012 Oral Presentation, 2012

McGlinchey, E., McCallion, P., Carroll, R., Burke, E., McCarron, M, Behavioural Health of Older Adults wiht an Intellectual Disability: Findings from the Intellectual Disability, 2012 IASSIDD World Congress , Halifax, Canada, 2012 Oral Presentation, 2012

McGlinchey, E., McCallion, P., Carroll, R., Burke, E., McCarron, M, Behavioural Health of Older Adults wiht an Intellectual Disability: Findings from the Intellectual Disability, Interdisciplinary Research Conference, Optimising Health in the 21st Century, 2012 Oral Presentation, 2012

McCallion, P., Swinburne, J., Burke, E., McGlinchey,E., Carroll, R., McCarron, M., Health Care Utilisation by Adults with an Intellectual Disability Ageing in Ireland., IASSID World Congress, Halifax, Canada, July, 2012 Oral Presentation, 2012

McGlinchey, E., McCallion, P., Swinburne, J., Carroll, R., McCarron, M., Life Long Learning and Employment in Older Irish Adults with an Intellectual Disability., IASSID World Congress, Halifax, Canada, July, 2012 Oral Presentation, 2012

McCarron, M., Swinburne. J., Burke. E., McGlinchey, E., & McCallion, P, Physical health and multiple morbidity in Irish people with an intellectual disabiltiy as they age., IASSID World Congress, Halifax, Canada, July , 2012 Oral Presentation, 2012

McGlinchey, E., Carroll, R., McCarron, M., McCallion, P, The importance of learning and employment opportunities in social development and well being of older adults wiht an intellectual disability in Ireland, IDS@UL, 2012, 2012 Oral Presentation, 2012

Non-Peer-Reviewed Publications

Darren McCausland, Andrew P. Allen, Margaret Haigh, Fintan Sheerin, Eilish Burke, Eimear McGlinchey, Fidelma Flannery, Niamh Mulryan, Philip McCallion and Mary McCarron, Overcoming Adversity: The Continuing Impact of COVID-19 on People Ageing with an Intellectual Disability in Ireland. Findings from the Intellectual Disability Supplement to The Irish Longitudinal Study on Ageing (IDS-TILDA) COVID-19 Sub-Study, Trinity College Dublin, December, 2021 Report, 2021 TARA - Full Text DOI URL

Marianne Fallon & Dr. Eimear McGlinchey, Promoting Brain Health Across the Lifespan: People with an Intellectual Disability, Learning Disabilities and Dementia Community of Practice meeting, Online- Wales, 15th July 2021, 2021, Rebecca Hamner, Public Health Wales Invited Talk, 2021

McCarron, M., McCausland, D., Allen, A.P., Luus, R., Sheerin, F., Burke, E., McGlinchey, E., Flannery, F., & McCallion, P., THE IMPACT OF COVID-19 on People Ageing with an Intellectual Disability in Ireland 2020 - Evidence from Wave 4 of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA), Dublin, December, 2020 Report, 2020 URL

McCarron, Mary; McCausland, Darren; Allen, Andrew; Luus, Retha; Sheerin, Fintan; Burke, Eilish; McGlinchey, Eimear; Flannery, Fidelma; McCallion, Philip, The impact of COVID-19 on people ageing with an intellectual disability in Ireland, Dublin, December, 2020 Report, 2020 URL DOI TARA - Full Text

2. McGlinchey, E., Burke, E., McCallion, P., Haigh, M., O'Donovan ,M., McCarron, M. , Health and Well-Being of Older Adults in St Joseph's Intellectual Disability Service: Baseline Report., Trinity Centre for Ageing and Intellectual Disability, Dublin, 2018 Report, 2018

Mary McCarron, Philip McCallion, Rachael Carroll, Eilish Burke, Eimear McGlinchey, Mary-Ann O'Donovan, Darren McCausland, Fintan Sheerin, Maire O'Dwyer, Sinead Foran, Caoimhin MacGiolla Phadraig, Niamh Mulryan, Juliette O'Connell and Judy Ryan., Health, Wellbeing and Social Inclusion: Ageing with an Intellectual Disability in Ireland Evidence from the First Ten Years of The Intellectual Disability Supplement to The Irish Longitudinal Study on Ageing (IDS-TILDA) Wave 3 IDS-TILDA, Trinity College Dublin, 2017 Report, 2017 DOI TARA - Full Text

McCarron, M., Burke, E., McGlinchey, E., McCausland, D., O'Dwyer, M., O'Donovan, M.A., McCallion, P., Value for Money and Policy Review of Disability Services in ireland, Value for Money and Policy Review of Disability Services in ireland, Hawkins House, 2015 Oral Presentation, 2015

McCarron. ,M., McCallion, P., Carroll, R., Burke, E., McGlinchey, E., McCausland, D., Cleary, E., Shivers, C., Advancing Years, Different Challenges: Wave 2 IDS-TILDA, 2014 Report, 2014

McGlinchey, E., McCausland, D., McCarron, M., Burke, E., McCallion, P. , Advancing Years, Different Challenges: Wave 2 IDS-TILDA: An Accessible Report. , Dublin: Trinity College Dublin, 2014 Report, 2014

Mary McCarron, Philip McCallion, Rachael Carroll, Eilish Burke, Eimear Cleary, Darren McCausland, Eimear McGlinchy, Mary Ann O'Donovan, Niamh Mulryan, and Carolyn Shivers, Advancing Years, Different Challenges: Wave 2 IDS-TILDA. Findings on the ageing of people with an intellectual disability., Dublin, 2014 Report, 2014

McCarron, M., Swinburne, J., Burke, EA., McGlinchey, E., Mulryan, N., Andrews, V., Foran, S. and McCallion P. , Growing Older with an Intellectual Disability in Ireland, First results from the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing -An Accessible Report. , Accessible version, Trinity College Dublin, 2011 Report, 2011

McCarron. M., Swinburne. J., Burke, E., McGlinchey, E., Mulryan, N., Andrews, V., Foran, S., & McCallion. P., Growing Older with an Intellectual Disability in Ireland 2011; First Results from the The Intellectual Disability Supplement to The Irish Longitudinal Study on Ageing., 2011 Report, 2011 TARA - Full Text DOI

Research Expertise

Projects

  • Title
    • Including the Voices of Experience in Developing Accessible Post-Diagnostic Dementia Support Guidelines for People with an Intellectual Disability
  • Summary
    • People with an Intellectual Disability (ID) are at greater risk of developing dementia than the general population. In particular, those with Down syndrome (DS) are the world's largest group with a genetic risk for Alzheimer's disease (AD), given overexpression of the amyloid precursor protein (APP) gene located on chromosome 21. Despite this high risk, services, both in the general population and ID specific services are ill prepared to provide post-diagnostic support to people with an ID and dementia and their carers, meaning unequal and inadequate access to supports for many across the country. There is currently little systematic research to guide development of post-diagnostic supports for people with ID. With its recent establishment, the National Intellectual Disability Memory Service (NIDMS) in Ireland will offer an accessible systematic approach to diagnosis, resulting in an increased need for post-diagnostic supports for people with ID. The aim of the study, therefore, is to develop accessible best practice guidelines for post-diagnostic dementia supports for people with an intellectual disability in Ireland. This will be achieved through: 1) Identifying current guidelines/recommendations on post-diagnostic dementia care nationally and internationally for the general population and for people with ID. 2) Understanding the current landscape of post-diagnostic dementia support for people with an intellectual disability in Ireland. 3) Understanding the lived experience of accessing and using post-diagnostic dementia support services for people with ID/DS and their families and desires for post-diagnostic services. 4) Identifying gold standard approaches/guidelines to post diagnostic dementia care from specialist ID service providers. The resulting guidelines will identify needed adjustments, and make recommendations for all services on how best to provide post-diagnostic dementia supports to people with ID and their families/carers.
  • Funding Agency
    • Health Research Charities Ireland
  • Date From
    • 01/01/2021
  • Date To
    • 31/12/2022
  • Title
    • PREVENT dementia -DS
  • Summary
    • This study will examine the effect of Alzheimer's disease pathology on the organisation of brain networks in people with Down syndrome compared to people in the general population who are at high risk of Alzheimer's disease and people who are at low risk of Alzheimer's disease. People with Down syndrome are at high risk of Alzheimer's disease (AD) because genetic reasons. However, they are typically excluded from Alzheimer's disease prevention research. Including people with Down syndrome in this type of research is important from an equity perspective and could also help us to understand the development and progression of Alzheimer's disease for all. The PREVENT study, is part of an international study examining early biomarkers of Alzheimer's disease in the general population in mid-life and before clinical stages of the disease. This pilot will adapt the PREVENT protocol so that it is suitable for people with Down syndrome. The neuroimaging, blood and neuropsychological data collected in this process will then be analyzed. The organisation of brain networks in people with Down syndrome who don't have any symptoms of Alzheimer's disease will be compared to people from the PREVENT study at high risk for Alzheimer's disease and at low risk for Alzheimer's disease. Neurofilament light protein is a protein that can be measured in the blood and has been found to be a reliable marker of Alzheimer's disease pathology in people with Down syndrome. The association between this protein in relation to the organisation of brain networks in people with Down syndrome will be examined. The relationship between the organisation of brain networks and scores on neuropsychological assessments will be examined. This will give us a better understanding of the early cognitive changes as a result of Alzheimer's disease in people with Down syndrome. Through establishing the adapted PREVENT protocol, this pilot will inform the development of a large national study - PREVENT dementia - DS.
  • Funding Agency
    • Alzheimer's Association, Alzheimer's UK, Global Brain Health Institute
  • Date From
    • 01/09/2021
  • Date To
    • 31/08/2022
  • Title
    • arly Biomarkers of Alzheimer's Disease in People with Down syndrome
  • Summary
    • People with Down syndrome (DS) have a genetic predisposition to Alzheimer's disease (AD) but have typically been excluded from AD prevention research. Including people with DS is important from an equity perspective and to provide insight into the development and progression of Alzheimer's disease. The PREVENT study, is part of an international study examining early biomarkers of AD in the general population in mid-life and before clinical stages of the disease. This pilot will adapt the PREVENT protocol so that it is suitable for people with DS, and will include people from 20-29, before the onset of AD pathology. Neuroimaging, blood and neuropsychological data collected will be analysed. Specifically, the organisation of brain networks in people with DS prior to the onset of AD pathology will be analysed and it's association with Neurofilament Light (NfL), a protein measured in blood examined. NfL has been found to be a reliable marker of AD pathology in people with DS. This study will give a better understanding of the earliest changes in the AD process in people with DS. Through establishing the adapted PREVENT protocol, this project will inform the development of a large national study - PREVENT dementia - DS.
  • Funding Agency
    • Deans Rersearch Initiative
  • Date From
    • 01/07/2021

Recognition

Representations

Journal Reviewer Journal of Intellectual Disability Research 2018-2020

Reviewer for Research in Developmental Disabilities 2019-2020

Reviewer for Journal of Applied Research in Intellectual Disabilities 2018-2020

Journal Reviewer for Journal of Intellectual Disabllities

Journal reviewer for International Journal for Geriatric Psychiatry 2021

Journal reviewer for Environmental Research and Public Health 2021

Journal reviewer for Journal of Policy and Practice in Intellectual Disabilities 2021

Journal reviewer for Neurobiology of Ageing 2021

Memberships

International Association of the Scientific Study of Intellectual and Developmental Disabilities (IASSIDD) 2017 – 2020

Trisomy 21 Research Society (T21RS) 2019 – 2020